Endocrine Abstracts

Introduction: Nephrolithiasis and bone disease are the most common complications of primary hyperparathyroidism (PHPT). The aim of this study was to evaluate the relationships between the existence of kidney stones, renal function and bone mineral density (BMD) in PHPT.Description of methods/design: Biomedical evaluation, BMD measurements and renal ultrasonography were performed in a group of 75 consecutive PHPT patients aged 57.6±12.7 years. The co...

The adrenal incidentalomas have become a common clinical problem. In the vast majority of cases these masses are non- secreting adrenocrotical adenomas. However, some may show minor endocrine abnormalities with a subclinical hyperfunction or represent malignancies.Objectives: The aim of the study was to analyze and follow-up of incidentalomas and to establish the risk factors for mass enlargement and/or hormonal disturbances.Materi...

Context: Polycystic ovary syndrome (PCOS) is a very common endocrinopathy affecting approximately 6–18% of women of reproductive age. It is also the most common cause of infertility due to anovulation. PCOS is characterized by menstrual disorders, polycystic or enlarged ovaries on ultrasound, but hyperandrogenism is the central feature of PCOS. Assessing of serum testosterone level (T) or free T is recommended by the guidelines in the diagnosis of PCOS. Diagnostic value o...

Introduction: Acute cardiac insufficiency induced by stress (Takotsubo cardiomyopathy (TTC)) is a reversible cardiomyopathy induced by severe emotional stress or severe clinical conditions. It is characterised by transient left ventricular systolic dysfunction and electrocardiographic changes. This cardiomyopathy has been described in some severe neurological conditions and in patients with pheochromocytoma. To date, some cases of this cardiomyopathy have been described in pat...

Context: Both polycystic ovary syndrome (PCOS) and chronic autoimmune thyroiditis (AIT, Hashimoto disease) are common endocrinopathies and the AIT is the most prevalent cause of hypothyroidism in areas with sufficient iodine intake. Patients with PCOS are probably more susceptible to the development of autoimmune diseases. The data about the prevalence of AIT in PCOS is limited and it has not been assessed in the Polish population.The aims of the study w...

Widespread use of CT and MRI scan has led to the identification of incidental adrenal tumours. The need to determine functionality often results in a battery of investigations that are a drain to scarce resources and are frequently normal. Studies to identify tumour radiological features that suggest functionality and hence enable targeted investigations are few in the literature. To this effect we set out to analyse which features on imaging that are best predictive of functi...

Introduction: Primary hyperparathyroidism (PHPT) is generally associated with increased fracture risk at all skeletal sites although greater bone loss is observed at the cortical than the trabecular bone sites. AsBMD alone does not adequately predict fracture risk, trabecular bone score (TBS) is proposed as a new method supporting risk assessment.The aim of this study was to investigate correlation between TBS andthe severity of primary hyperparathyroidi...

Background: Calcium and vitamin D malabsorption in celiac disease (CD) predispose to high bone turnover and skeletal demineralization. Osteoprotegerin (OPG), a member of the tumor necrosis factor receptor family, and ligand of receptor activator of NFkB (RANKL) inhibits osteoclast formation and activity.The aim of this study was to evaluate the relationship between bone mineral density (BMD), bone-turnover markers and osteprotegerin in adult patients wit...

Introduction: The T,B and antigen presenting cells play a key role in the pathogenesis of autoimmune diseases.The aim of the studies was to analyse different regulatory cells subsets interaction in patients with Graves’ disease.Material and methods: We have studied paraffin thyroid specimens obtained from 10 children with Graves’ disease after thiamazole treatment. The thyroid tissue was stained with hematoksylin-eosin (H...

Background/Aims: Calcium and vitamin D malabsorption in celiac disease predispose to skeletal demineralization. The aim of this study was to evaluate the prevalence of bone mineral density (BMD) and calcium deficiencies in adult patients with CD and assess whether a gluten-free diet is sufficiently effective for BMD restoration or whether calcium and vitamin D should be applied.Methods: BMD and biochemical parameters of bone and mineral metabolism were m...